Fig. 8.

TekΔMyd88-mediated disruption of IL-1β signaling in all endothelium and microglia eliminates sickness response. Twenty-four-hour profiles of telemetric and feeding data shows the stereotypical IL-1β-induced elevation in core body temperature (ΔCBT, a) and decrease in voluntary locomotor activity (VLA, b) and food intake (FI, c) in Myd88 ^fl/fl (fl/fl) but not TekΔMyd88 (KO) mice. IL-1β-treated control ΔCBT, VLA and FI were significantly different from vehicle (Veh)-treated values for several hours following treatment (p < 0.05 for times below black bar above traces in a–c). IL-1β-treated KO animals were not different from Veh-treated animals at any time. Gray boxes show dark phase, when mice are most active. All values shown are mean ± SEM for group sizes listed in the legend above a