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. 2017 Oct 16;9(8):1262–1269. doi: 10.1080/19420862.2017.1305529

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© 2017 Molecular Partners AG. Published with license by Taylor and Francis group, LLC

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Figure 4. — Comparison of His-tagged MP0250 (circles) in comparison to individual DARPin® domains (triangles) in cellular assays. (a) HUVEC proliferation inhibition assay. MP0250 is equivalently potent as the individual VEGF-inhibiting DARPin® domain of MP0250 in inhibiting HUVEC proliferation. Reference (square): sample with no inhibitor present. (b) c-Met phosphorylation inhibition assay. MP0250 is equivalently potent as the individual HGF-inhibiting DARPin® domain of MP0250 in inhibiting c-Met phosphorylation. The cellular assays were performed as described in the Materials & Methods section.