Table 4.
Cox regression multivariate analyses of factors associated with early mortality and early recurrence in hepatocellular carcinoma after hepatectomy
| Multivariate analysis | ||
|---|---|---|
| Hazard ratio (95% CI)j | P -value | |
| Early Mortality | ||
| RAM scorea | ||
| class II/III vs. class I | 2.847 (1.884~4.302) | <0.001 |
| ALBI scoreb | <0.001 | |
| grade 2 vs. grade 1 | 2.309 (1.577~3.383) | <0.001 |
| grade 3 vs. grade 1 | N/Ak | 0.953 |
| MELD scorec | 0.271 | |
| grade 2 vs. grade 1 | 1.218 (0.782~1.897) | 0.384 |
| grade 3 vs. grade 1 | 1.873 (0.830~4.231) | 0.131 |
| Alcohol consumption (Yes) | 1.799 (1.105~2.930) | 0.018 |
| Cigarette smoking (Yes) | 1.110 (0.710~1.734) | 0.648 |
| Age > 80 (year-old) | 1.988 (0.907~4.354) | 0.086 |
| Pre-OP symptomsd (Yes) | 1.411 (0.956~2.083) | 0.083 |
| Pre-OP treatmente (Yes) | 1.271 (0.765~2.111) | 0.355 |
| Pre-OP platelets < 100 (1000/uL) | 1.453 (0.905~2.332) | 0.122 |
| Pre-OP total bilirubin > 2.0 (mg/dL) | 1.377 (0.469~4.039) | 0.561 |
| Pre-OP hemoglobin < 10 (g/dL) | 1.102 (0.596~2.038) | 0.756 |
| ICG-15f > 10 (%) | 1.081 (0.740~1.580) | 0.687 |
| OP durationg > 270 (mins) | 1.295 (0.875~1.915) | 0.196 |
| Tumor size > 10 (cm) | 1.770 (1.130~2.771) | 0.013 |
| Early Recurrence | ||
| RAM scorea | ||
| class II/III vs. class I | 1.640 (1.352~1.988) | <0.001 |
| ALBI scoreb | 0.001 | |
| grade 2 vs. grade 1 | 1.382 (1.190~1.606) | <0.001 |
| grade 3 vs. grade 1 | 0.962 (0.301~3.077) | 0.948 |
| MELD scorec | 0.868 | |
| grade 2 vs. grade 1 | 0.952 (0.787~1.150) | 0.608 |
| grade 3 vs. grade 1 | 1.015 (0.683~1.509) | 0.941 |
| Alcohol consumption (Yes) | 1.249 (1.003~1.557) | 0.047 |
| Cigarette smoking (Yes) | 1.258 (1.057~1.498) | 0.010 |
| Pre-OP symptomsd (Yes) | 1.006 (0.855~1.184) | 0.943 |
| Pre-OP treatmente (Yes) | 1.183 (0.953~1.469) | 0.127 |
| Pre-OP total bilirubin > 2.0 (mg/dL) | 1.513 (0.921~2.487) | 0.102 |
| Pre-OP hemoglobin < 10 (g/dL) | 1.215 (0.903~1.634) | 0.199 |
| Pre-OP ALTh > 40 (U/L) | 1.077 (0.940~1.234) | 0.284 |
| ICG-15f > 10% | 1.347 (1.167~1.554) | <0.001 |
| Tumor size > 10 (cm) | 1.773 (1.456~2.160) | <0.001 |
| Inflow controli (Yes) | 1.162 (0.985~1.370) | 0.075 |
aRisk Assessment for early Mortality score
balbumin–bilirubin score
cModel for End-Stage Liver Disease score
dpreoperative symptoms included anemia, jaundice, palpable mass and ascites
epreoperative treatments included transarterial chemoembolization, percutaneous ethanol injection and radiofrequency ablation
findocyanine green retention test at 15 min
gduration of operation
hpreoperative serum alanine aminotransferase level
iinflow control included as Pringle’s maneuver, Glissonian pedicle control, selective vascular control and total vascular exclusion
j95% confidence interval
kNot Applicable