Table 1.
Parameter estimates of the TMDD model after IV bolus.
| Population mean parameter |
Intersubject variance |
|||||
|---|---|---|---|---|---|---|
| Parameter | Description | Units | Estimate | RSE (%) | Estimate | RSE (%) |
| Vc | Volume of central compartment | mL | 1.12 | 5 | 0.115 | 26 |
| Kd | constant of dissociation | nM | 4.13 | 5 | 0.145 | 25 |
| koff | dissociation rate (binding) | 1/day | 12.31 | 2 | 0.0662 | 26 |
| Rbase | baseline target concentration | nM | 647 | 4 | — | — |
| Number of receptors/hepatocytes* | — | 1.8 million | — | — | — | |
| keRL | rate of internalization | 1/day | 0.139 | 3 | 0.0599 | 39 |
| kdeg | turnover rate of the target | 1/day | 1.06 | 13 | 0.413 | 23 |
| keL | Rate of elimination from central compartment | 1/day | 0.449 | 13 | 0.302 | 37 |
| Q | exchange between central and peripheral compartment | mL/day | 20.28 | 13 | 0.296 | 40 |
| Vp | volume of the peripheral compartment | mL | 3.79 | 18 | 0.58 | 24 |
| ksyn | Synthesis rate (secondary parameter) | nM/day | 715.84 | — | — | — |
| b | proportional error | — | 0.114 | 8 | — | — |