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Generation of iPSCs from human AFCs with trisomy 18. (a) Phase contrast of the indicated iPSC clones of the early passage (passage 6). Bar, 200 μm.(b) Karyotype analysis of each iPSC lines.Chromosome 18 are marked in a red circle. (c) Copy number state of Chromosome 18 in each iPSC lines identified by CNV array with the AffymetrixCytoScan Assay. N-3: normal iPSCs derived from healthy AFC; Trisomy 18 iPSCs cell line: Tri-7-3, Tri-11-1, and Tri-11-2
