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. 2017 Oct 26;8(10):e3149. doi: 10.1038/cddis.2017.565

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Increased spontaneous differentiation in 18T-iPSCs. (a) Phase contrast of the differentiated colonies from each of the three 18T-iPSC lines and the control iPSC line. Differentiated areas are indicated by white arrows. Bar, 200 μm. (b) Percentage of differentiated colonies in each cell lines were calculated. N-3 iPSCs were used as a control. Experiments were repeated for three times. Error bars represent S.D., and P-values were determined by the Student’s t-test. *P<0.05, **P<0.01. (c) Immunostaining images showed that cells lacking expression of OCT4 (green) in the differentiated areas expressed only SOX2 (red). Bar, 200 μm. N-3: normal iPSCs derived from healthy AFC; Trisomy 18 iPSCs cell line: Tri-7-3, Tri-11-1, and Tri-11-2