Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 8;26(9):1538–1541. doi: 10.1177/0963689717721227

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Fig. 1. — The ability of mesenchymal stem cells (MSCs) to differentiate into cells expressing markers of retinal cells, to inhibit expression of genes for pro-inflammatory molecules, and to produce growth and differentiation factors. (A) MSCs were cultured for 7 d alone (-) or in the presence of retinal extract (E), in the presence of supernatant from activated T lymphocytes (S), or in the presence of E and S. The expression of genes for rhodopsin and S-antigen was determined by real-time PCR. The explants of the posterior segment of the eye were cultured for 48 h alone (-), with interleukin (IL)-17 and interferon (IFN)-γ (Cy), or were stimulated with cytokines in the presence of MSCs. The expression of genes for pro-inflammatory molecules IL-1β and inducible nitric oxide synthase was determined by PCR. Production of TGF-β and IGF-2 by MSCs. MSCs were cultured for 48 h unstimulated (-) or in the presence of IL-17 and IFN-γ (Cy). The expression of genes for TGF-β and IGF-2 was determined by real-time PCR. Each bar represents the mean (SD) from at least 3 independent determinations. Values with asterisk represent statistical significance (P < 0.05; A) gene expression, (B) inhibition of cytokine production, and (C) expression of genes for growth factors.