Table 2.

Quality of evidence for primary outcome categorised by conclusiveness

Characteristic	All n = 103 n (%) or median (IQR)	Conclusive n = 51 n (%) or median (IQR)	Inconclusive n = 52 n (%) or median (IQR)
Number of outcomes assigned a GRADE rating	6 (4, 7)	6 (4, 7)	5 (3, 6)
High-quality evidence for primary outcome	11 (11)	8 (16)	3 (6)
Moderate-quality evidence for primary outcome	35 (34)	23 (45)	12 (23)
Low-quality evidence for primary outcome	42 (40)	17 (33)	25 (48)
Very low-quality evidence for primary outcome	15 (15)	3 (6)	12 (23)
Primary outcome downgraded because of risk of bias	44 (43)	18 (36)	26 (50)
Primary outcome downgraded because of imprecision	36 (35)	11 (22)	25 (48)
Primary outcome downgraded because of inconsistency	18 (18)	8 (16)	10 (19)
Primary outcome downgraded because of publication bias	18 (18)	11 (22)	7 (13)
Primary outcome downgraded because of indirectness	7 (7)	2 (4)	5 (10)

GRADE, Grades of Recommendation, Assessment, Development and Evaluation.