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. 2017 Aug 18;6(11):1407–1418. doi: 10.1016/j.molmet.2017.08.005

Figure 5.

Figure 5

In vitro effects of chronically-elevated glucose and palmitate on the level of two lncRNAs differentially expressed in islets from mice fed a high fat diet. Isolated islets from C57BL/6 mice fed a regular chow diet were incubated for 48 h at 6, 11 or 20 mM glucose and at 6 mM glucose with or without 0.5 mM palmitate (RPMI supplemented with 5% FCS, 0.5% BSA and 11 mM glucose). LncRNA expression was measured by real-time PCR and normalized to Gapdh. Means ± SEM of 3–4 different experiments. t-test or ANOVA, Tukey post-hoc test, *P < 0.05 vs control, either glucose 6 mM or no palmitate.