Figure 5.
miRNA expression levels between subject groups and correlations with in vivo mitochondrial function in human skeletal muscle. (A) Figures (left panels) show correlations for miRNA expression levels plotted against in vivo measures for mitochondrial function, i.e. PCr recovery rate (seconds) and maximal aerobic capacity (VO2max) for all subjects, with the Spearman ρ and p-value given for each miRNA. (B) Relative miRNA expression (middle panels) in type 2 diabetic (T2DM), obese (O), lean sedentary (LS), and Athletic (A) subjects (n = 12). Significance was assessed using one-way ANOVA with the nonparametric Kruskal–Wallis correction for multiple testing, and is indicated with *, **, and *** representing p < 0.05, p < 0.01, and p < 0.001 respectively. (C) Correlations between group means of relative miRNA expression and in vivo mitochondrial function (right panels). Values are means ± SD.