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. 2017 Aug 31;6(11):1429–1442. doi: 10.1016/j.molmet.2017.08.007

Figure 6.

Figure 6

MiRNA-150-5p, miRNA-34c-3p, miRNA-196b-3p, and miRNA-320a alter the expression of genes involved in mitochondrial metabolism in C2C12 myotubes. (A) Hierarchical clustering of the expression of 27 genes involved in different aspects of mitochondrial function, 24 h after individually transfecting LNAs directed against miRNA-150-5p, miRNA-34c-3p, miRNA-196b-3p, and miRNA-320a vs. negative control (NC). Blue and red represent down and up regulation, respectively (B) mRNA levels of miRNA-150-5p predicted target PPARGC1a and its downstream target mtTFA, 24 h post transfection with an anti-miRNA-150-5p. (C) Representation of the binding between the PGC-1α mRNA 3′UTR region and miRNA-150-5p in different species. Mean+/-SD, *p < 0.05; #p = 0.06 (n = 3).