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. 2017 Sep 15;6(11):1540–1550. doi: 10.1016/j.molmet.2017.08.013

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effect of genotype on core body temperature. Tb was measured by telemetry, sampling for 24 h in singly-housed, free-ranging mice in their home cage. Ambient temperature was ∼22 °C and each comparison is between groups studied simultaneously. We define the Tb range as the difference between the 95th and 5th percentiles. (A) Re-analysis of Tb in WT and global Brs3^-/y mice from [26] showed a 0.54 °C larger range in the global Brs3^-/y mice compared to controls (p = 0.00008). (B) Brs3^fl/y;Vglut2-Cre (Vglut2-Cre) mice had a 0.59 °C larger range than littermate Brs3^fl/y (flox/y) mice (p = 0.008). (C) Brs3^fl/y;Vgat-Cre (Vgat-Cre) and littermate Brs3^fl/y (flox/y) mice showed no difference in Tb range (p = 0.78). Additional analyses of the Tb phenotype are in Table S1.