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. 2017 Sep 15;6(11):1540–1550. doi: 10.1016/j.molmet.2017.08.013

Figure 5.

Figure 5

Effect of MK-5046 and MTII on food intake and energy expenditure. (A–C) Brs3fl/y;Vglut2-Cre (Vglut2-Cre) and littermate control Brs3fl/y (flox/y) mice. (A) Effect of MK-5046 (10 mg/kg, i.p.) or vehicle on 2-h food intake. (B) Effect of MTII (3 mg/kg, i.p.) or vehicle on 2-h food intake. (C) Effect of MK-5046 or vehicle on energy expenditure (N = 6/group). Treatment is compared to pre-injection baseline. (D–F) Brs3fl/y;Vgat-Cre (Vgat-Cre) and littermate control Brs3fl/y (flox/y) mice were studied exactly as described in (A–C) (N = 10–12/group for food intake studies, 6/group for energy expenditure study). * indicates P < 0.05 drug vs vehicle, within genotype by paired t-test. # indicates P < 0.05 vehicle between genotypes by unpaired t-test.