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. 2017 Sep 14;6(11):1360–1370. doi: 10.1016/j.molmet.2017.09.001

Figure 5.

Figure 5

Co-administration of OCA and IP118 to diet-induced mice synergistically reduces body weight. Effect of OCA alone or in combination with twice-weekly doses of IP118 on (A) body weight, (B) percent change in body weight from basline, (C) change in adiposity (percent fat mass), and (D) change in percent lean mass. On day 17 of the study, glucose tolerance was explored in an intraperitoneal glucose tolerance test (E). Terminal liver lipid levels are shown in (F). *p < 0.05 vs. vehicle, ˆp < 0.05 vs. OCA, +p < 0.05 vs. IP118.