Table 2.

Summary of histopathology findings. Number of animals within each treatment classified as either none, mild, moderate, or marked for presence of various pathological features of NASH. The average NASH score was calculated as the sum of multiple hepatic pathological features of NASH described in Materials and Methods. LFD, low fat diet.

Strain	C57BL6J	ob/ob	ob/ob	ob/ob	ob/ob	ob/ob
Diet/drug	LFD	LFD	AMLN/vehicle	AMLN/OCA	AMLN/IP118	AMLN/OCA + IP118
Animals examined	6	8	10	10	10	10
Steatosis
None	4	0	0	0	0	0
Mild	2	0	0	0	0	0
Moderate	0	4	0	4	7	7
Marked	0	4	10	6	3	3
Steatosis location
None	5	2	0	1	2	1
Mild	0	0	0	0	0	0
Moderate	1	0	0	0	0	0
Marked	0	6	10	9	8	9
Microvesicular steatosis
None	6	7	2	0	6	3
Mild	0	1	8	10	4	7
Moderate	0	0	0	0	0	0
Marked	0	0	0	0	0	0
Hepatocyte ballooning
None	6	8	6	0	4	5
Mild	0	0	4	10	6	5
Moderate	0	0	0	0	0	0
Marked	0	0	0	0	0	0
Lobular inflammation
None	6	8	4	1	6	3
Mild	0	0	4	8	3	7
Moderate	0	0	2	0	1	0
Marked	0	0	0	1	0	0
CD68 immunoreactivity
None	6	0	0	0	0	0
Mild	0	8	2	4	6	7
Moderate	0	0	8	6	4	3
Marked	0	0	0	0	0	0
Biliary hyperplasia
None	6	1	0	0	0	0
Mild	0	7	0	4	4	6
Moderate	0	0	10	6	6	4
Marked	0	0	0	0	0	0
Fibrosis
None	6	0	0	0	0	0
Mild	0	8	2	1	1	4
Moderate	0	0	5	1	6	6
Marked	0	0	3	8	3	3
Fibrosis pattern
None	6	0	0	0	0	0
Mild	0	6	1	0	0	0
Moderate	0	2	7	3	5	7
Marked	0	0	2	7	5	3
Average NASH Score	0.7	9	16	17	13.9	13.5