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. 2017 Sep 27;6(11):1529–1539. doi: 10.1016/j.molmet.2017.09.004

Figure 1.

Figure 1

PBMC is an important source of increased plasma DPP4 activity in T2DM patients. DPP4 activity in plasma and peripheral blood mononuclear cells (PBMC) of treatment naïve type 2 diabetes (T2DM) patients and healthy control subjects. DPP4 expression in PBMC was measured and linear regression analysis was performed with Spearman correlation. (A–C) Comparison of plasma (control n = 78 & T2DM n = 135) PBMC DPP4 activity (control n = 46 & T2DM n = 35) and PBMC DPP4 gene expression (control n = 49 & T2DM n = 41). (D–G) Linear regression analysis of PBMC DPP4 activity with plasma DPP4 activity (D&F), and PBMC DPP4 activity and gene expression (E&G). (H, I) PBMCs from control (n = 22) and treatment naïve T2DM subjects (n = 28) were cultured for 48 h and supernatant (H) as well as cellular DPP4 levels (I) were analyzed by ELISA. Statistical analysis was performed by Mann–Whitney U test and Student's t test with Spearman correlation; *p < 0.05, ***p < 0.001.