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. 2017 Sep 18;6(11):1454–1467. doi: 10.1016/j.molmet.2017.09.003

Figure 6.

Figure 6

BAT-restricted activation of hFGFR1c transgene by human specific FGFR1 agonist does not stimulate EE. (A) Schematic representation of chimeric Ucp1-hmFGFR1c transgenic construct. (B) Tissue expression pattern of the transgene assessed by qPCR. (C) Gene expression in iBAT and eWAT of Ucp1-hmFGFR1c transgenic mice treated with control IgG or 14B6 at 10 mg/kg, assessed by qPCR. (D) Mean EE values from hFGFR1 transgenic mice treated with control IgG or 14B6, 10 mg/kg. (E) Quantification of the data shown in (D). Average EE per day per mouse pre- and post-doses are shown. (F) Average % body weight change 8 days post injection. (G) Serum HMW adiponectin 12 days after dose. (H) Area under the blood glucose curve during GTT in Ucp1-hmFGFR1c transgenic mice. In (D), error bars omitted for clarity. Error bars are mean ± SEM. p < 0.001 (***) vs control.