Table 2. Commonly administered drug regimens from the 129 studies collecting data on the efficacy of drugs for treating ascariasis, trichuriasis and hookworm.
These regimens account for the majority (89%) of IPD suitable for efficacy estimation. Other miscellaneous drugs or regimens administered include variations on the common mebendazole regimens, levamisole, diethylcarbamazine (DEC), and plant extracts tested for their anthelmintic effect. There are also some treatments which were not reported in enough detail to characterise.
| Drug name | Dosage regimen | Number of studies (cohorts) administering this regimen | Estimated number of IPD1 |
|---|---|---|---|
| Albendazole2 | 400 mg single dose3 400 mg, age > 12 years / 200 mg, age < 12 years, single doses |
64 (78) 6 (7) |
12,574 1,130 |
| other “albendazole-only” regimens4 | 25 (25) | 3,740 | |
| Mebendazole2 | 500 mg single dose3 | 18 (24) | 3,868 |
| 200 mg per day for 3 days | 9 (11) | 948 | |
| Tribendimidine | various | 6 (9) | 2,600 |
| Ivermectin | various, including with other anthelmintics | 16 (21) | 2,130 |
| Pyrantel / oxantel pamoate, or combination of both | various, including with other anthelmintics | 7 (7) | 1,838 |
| Nitazoxanide | various, including with other anthelmintics | 7 (9) | 644 |
| Placebo or untreated or treated with antiprotozoan drugs only | 21 (23) | 1,477 |
1 individual participant data suitable for efficacy estimation
2 alone or with placebo, praziquantel, or antiprotozoan drugs
3 World Health Organization recommended dose for mass drug administration
4e.g. over 400 mg, and/or multiple doses