Table 1A.
The activity data expressed as MIC (MBC or MFC) [µg/ml] and {MBC/MIC or MFC/MIC ratio} against the reference strains of microorganisms. The standard chemotherapeutics agents: nitrofurantoin (NIT), ciprofloxacin (CIP), cefuroxime (CFX) and fluconazole (FLU) were used as positive control.
| Species | MIC (MBC or MFC) [µg/ml] and {MBC/MIC or MFC/MIC ratio} of the tested compounds |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | NIT | CIP | CFX | FLU | ||
| Gram-positive bacteria |
Staphylococcus aureus ATCC 25923 |
7.81 (7.81) {1} |
7.81 (7.81) {1} |
15.62 (125) {8} |
31.25 (250) {8} |
3.91 (7.81) {2} |
1.95 (3.91) {2} |
1.95 (15.62) {8} |
3.91 (7.81) {2} |
3.91 (3.91) {1} |
3.91 (7.81) {2} |
0.061 (7.81) {128} |
15.62 (15.62) |
0.488 | 0.49 | na |
|
Staphylococcus aureus ATCC 6538 |
7.81 (7.81) {1} |
7.81 (7.81) {1} |
31.25 (62.5) {2} |
31.25 (62.5) {2} |
3.91 (7.81) {2} |
3.91 (3.91) {1} |
0.98 (3.91) {4} |
3.91 (7.81) {2} |
1.95 (3.91) {2} |
7.81 (15.62) {2} |
0.98 (1.95) {2} |
15.62 (15.62) |
0.244 | 0.98 | na | |
|
Staphylococcus aureus ATCC 43300 |
0.98 (3.91) {4} |
1.95 (3.91) {2} |
7.81 (15.62) {2} |
7.81 (15.62) {2} |
0.98 (1.95) {2} |
0.244 (0.488) {2} |
0.244 (0.488) {2} |
1.95 (3.91) {2} |
0.488 (0.98) {2} |
7.81 (15.62) {2} |
0.122 (0.244) {2} |
7.81 (15.62) |
0.244 | nd | na | |
|
Staphylococcus epidermidis ATCC 12228 |
0.98 (1.95) {2} |
0.98 (1.95) {2} |
3.91 (15.62) {4} |
3.91 (15.62) {4} |
0.061 (0.244) {4} |
0.061 (0.122) {2} |
0.244 (0.488) {2} |
0.48 (0.98) {2} |
0.061 (0.122) {2} |
0.244 (0.244) {1} |
0.002 (0.002) {1} |
3.91 (7.81) |
0.122 | 0.24 | na | |
|
Micrococcus luteus ATCC 10240 |
62.5 (125) {2} |
62.5 (250) {4} |
250 (1000) {4} |
62.5 (500) {8} |
62.5 (62.5) {1} |
500 (>1000) {>2} |
250 (>1000) {>4} |
250 (>1000) {>4} |
62.5 (125) {2} |
1000 (>1000) {>1} |
125 (125) {1} |
62.5 (62.5) |
0.976 | 0.98 | na | |
|
Bacillus subtilis ATCC 6633 |
0.98 (0.98) {1} |
1.95 (1.95) {1} |
3.91 (7.81) {2} |
3.91 (7.81) {2} |
0.002 (0.008) {1} |
0.244 (7.81) {32} |
0.98 (3.91) {4} |
1.95 (1.95) {1} |
3.91 (3.91) {1} |
1.95 (1.95) {1} |
0.244 (0.98) {4} |
3.91 (3.91) |
0.031 | 15.63 | na | |
|
Bacillus cereus ATCC 10876 |
7.81 (7.81) {1} |
7.81 (7.81) {1} |
31.25 (31.25) {1} |
62.5 (125) {2} |
0.98 (3.91) {4} |
3.91 (7.81) {2} |
0.98 (15.62) {16} |
3.91 (3.91) {1} |
1.95 (3.91) {2} |
1.95 (1.95) {1} |
0.488 (0.98) {2} |
7.81 (15.62) |
0.061 | 31.25 | na | |
| Gram-negative bacteria |
Bordetella bronchiseptica ATCC 4617 |
31.25 (125) {4} |
62.5 (500) {8} |
125 (500) {4} |
62.5 (250) {4} |
500 (>1000) {>2} |
500 (>1000) {>2} |
– | – | 125 (1000) {8} |
– | 1000 (>1000) {>1} |
125 (>1000) |
0.976 | nd | na |
|
Klebsiella pneumoniae ATCC 13883 |
7.81 (15.62) {2} |
7.81 (7.81) {1} |
125 (250) {2} |
125 (125) {1} |
31.25 (>1000) {>32} |
1000 (>1000) {>1} |
– | – |
125 (500) {4} |
– | – | 15.62 (31.25) |
0.122 | nd | na | |
|
Proteus mirabilis ATCC 12453 |
31.25 (62.5) {2} |
62.5 (125) {2} |
500 (1000) {2} |
250 (500) {2} |
250 (>1000) {>4} |
250 (>1000) {>4} |
– | – |
62.5 (250) {4} |
– | – | 62.5 (125) |
0.030 | nd | na | |
|
Salmonella typhimurium ATCC 14028 |
7.81 (7.81) {1} |
7.81 (7.81) {1} |
125 (500) {4} |
62.5 (125) {2} |
0.98 (7.81) {8} |
500 (>1000) {>2} |
– | – |
62.5 (250) {4} |
– | – | 31.25 (62.5) |
0.061 | nd | na | |
|
Escherichia coli ATCC 25922 |
7.81 (7.81) {1} |
3.91 (7.81) {2} |
125 (250) {2} |
62.5 (125) {2} |
0.98 (1.95) {2} |
1000 (>1000) {>1} |
– | – |
31.25 (31.25) {1} |
– | – | 7.81 (15.62) |
0.004 | nd | na | |
|
Pseudomonas aeruginosa ATCC 9027 |
500 (1000) {2} |
– |
250 (500) {2} |
62.5 (125) {2} |
– | – | – | – | – | – | – | – | 0.488 | nd | na | |
| Fungi |
Candida albicans ATTC 10231 |
125 (250) {2} |
500 (>1000) |
125 (500) {4} |
62.5 (125) {2} |
– | 500 (>1000) {>2} |
125 (>1000) {>8} |
250 (>1000) {>4} |
31.25 (62.5) {2} |
125 (250) {2} |
1000 (>1000) {>1} |
na | na | na | 0.98 |
|
Candida parapsilosis ATTC 22019 |
250 (500) {2} |
1000 (>1000) {>1} |
125 (1000) {8} |
62.5 (250) {4} |
– | 1000 (>1000) {>1} |
500 (>1000) {>2} |
500 (>1000) {>2} |
125 (1000) {8} |
1000 (>1000) {>1} |
1000 (>1000) {>1} |
na | na | na | 1.95 | |
na - not applicable; nd – not determined; ‘-’ – no activity; MIC – Minimal Inhibitory Concentration; MBC – Minimal Bactericidal Concentration; MFC - Minimal Fungicidal Concentration; Compounds with bactericidal effect (MBC/MIC ≤ 4) or fungicidal effect (MFC/MIC ≤ 4) are marked in bold.