Fig. 7.
DMF attenuates TAUP301L-induced microgliosis. A) Photographs show immunohistochemistry for the microglial marker IBA1 in 30 µm-thick sections of hippocampus. Microglial morphology was classified as resting (type A), initiating microglial activation (type B), activated but non-phagocytic (type C) and phagocytic (type D) according to Sanchez-Guajardo et al. [22]B) Graphs indicate microglial cell number as the ratio of ipsilateral/contralateral sides. qRT-PCR determination of mRNA levels for Iba1 (C) and iNOS (D) in the contralateral and ipsilateral sides of the hippocampus. Differences among groups were assessed by two-way ANOVA followed by Bonferroni's test. Asterisks denote significant differences *p < 0.05, **p < 0.01, ***p < 0.001 comparing the indicated groups.