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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Breast Cancer Res Treat. 2017 Aug 19;166(3):855–864. doi: 10.1007/s10549-017-4439-6

Table 4.

Contribution of Estrogen Receptor (ER) Quantitative Measures to Breast Cancer Specific-Mortality Models.

Prognostic Factor Univariate Modela Chi-Square dfc p-value Multivariate Modelb Chi-Square df p-value
ER intensity 7.2 2 .03 6.24 2 .04d
Allred score 6.6 4 .16 5.43 4 .24d
a

Univariate model includes the variable of interest + missing value indicator only.

b

Multivariate model included adjustment for age at diagnosis, tumor size (<2 cm, 2–<5 cm, ≥5 cm, skin/chest wall involvement), positive lymph nodes (0, 1–3, 4+) tumor grade (1, 2, 3/4), progesterone receptor (PR) status, Her2/neu status, and Hispanic ethnicity. Excluded was ER percent positive staining.

c

DF – degrees of freedom

d

The contribution of ER intensity alone to the multivariate model was compared to the contribution from a combined ER intensity-ER positivity measure (the Allred score). Both ER intensity and Allred scores were modeled as dummy variables, with Allred categories of 3 and 4 combined due to small cells sizes (Table 1).