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. 2017 Nov 6;8:1438. doi: 10.3389/fimmu.2017.01438

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Copyright © 2017 Kruzel, Zimecki and Actor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lactoferrin (LTF) protects against lipopolysaccharide (LPS)-induced damage to mouse intestinal structures. LTF administered intraperitoneally prior to injection of LPS significantly limited damage to intestinal microvilli. High-power micrographs reveal that the saline/LPS-treated mice (A) demonstrate severe villus atrophy (#), edema, and epithelial vacuolation (*) compared with the LTF-treated counterparts (B). Tissue was stained with hematoxylin and eosin as described in Ref. (1). Photomicrographs were previously described in detail, and published in Actor et al. (1). Visualized at 400× magnification.