. 2017 Nov 6;8:1438. doi: 10.3389/fimmu.2017.01438

Table 1.

Type and degree of changes in livers of rats with obstructive jaundice.

Type of change	Treatment	Mean	Median	Statistics	No change	Light change	Moderate change	Significant change	Total
Foci with necrosis with disseminated lymphocytes	Control	2.29	9.73	p ≤ 0.001	0	2	6	6	32
Foci with necrosis with disseminated lymphocytes	LTF	0.17	0.39	p ≤ 0.001	10	2	0	0	2
Necrocytosis of single hepatocytes	Control	1.29	0.61	p ≤ 0.001	0	11	2	1	18
Necrocytosis of single hepatocytes	LTF	0.25	0.45	p ≤ 0.001	9	3	0	0	3
Proliferation of the bile ducts with their dilations	Control	2.29	0.73	p ≤ 0.001	0	2	6	6	32
Proliferation of the bile ducts with their dilations	LTF	0.58	0.51	p ≤ 0.001	5	7	0	0	7
Proliferation of fibrous and reticular connective tissue	Control	1.00	0.00	p ≤ 0.001	0	14	0	0	14
Proliferation of fibrous and reticular connective tissue	LTF	–	–	p ≤ 0.001	12	0	0	0	0

Changes seen in liver tissue samples were scored as none, light, moderate, and significant, as described (108). The non-parametric Mann–Whitney’s test was applied to data, with results given as mean and median values. Significant differences are indicated; n ≥ 12 per group. Data previously published by Zimecki et al. (108).