Table 1.

Profiles of hedgehog (Hh) signaling in major liver cells types.

Cell types	Hh-producing cells	Hh-responsive cells	Hh-targeted intervention responsive	Known Hh-dependent functions	Reference
Classical immune cells
Natural killer T cells	P	R	Yes	Inducing the recruitment and hepatic migration; promoting the proliferation and survival; regulating the pro-fibrogenic effect	(33, 39–41)
Kupffer cells/Macrophages	P	R	Yes	Chemotaxis and the regulation of phenotypes	(42–44)
T lymphocytes	Not clear	R	Not clear	Being recruited into injured liver through chemokines released by cholangiocytes in a Hh-dependent manner	(33, 45–47)
B lymphocytes	Not clear	R	Not clear	Being recruited into injured liver through chemokines released by cholangiocytes in a Hh-dependent manner	(7, 33, 48, 49)
Neutrophils	Not clear	R	Not clear	Being recruited into injured liver through chemokines released by cholangiocytes in a Hh-dependent manner	(33, 50–52)
Myeloid-derived suppressor cells	Not clear	R	Not clear	Not clear	(53)
Non-classical immune cells
Hepatocytes	Dying hepatocytes	R	Yes	Producing IGFI and IGFBP-1	(23, 54)
Cholangiocytes	P	R	Yes	Influencing viability and differentiation; inducing epithelial–mesenchymal transition (EMT) and the production of chemokines	(25, 33)
Liver sinusoidal endothelial cells	P	R	Yes	Regulating capillarization	(55)
Hepatic stellate cells (HSCs)	Activated HSCs	R	Yes	Inducing EMT	(17, 22)