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. 2017 Nov 6;8:890. doi: 10.3389/fphys.2017.00890

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Copyright © 2017 Lane and Tinker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic cardiac action potentials from different regions of the heart, with the currents that generate them. Colored lines indicate the phase of the action potential that the current participates in. Inward currents are in red, outward currents in blue. Currents - I_Na, inward Na⁺; I_CaT, T-type Ca²⁺; I_CaL, L- type Ca²⁺; I_to,f, fast transient outward; I_to,s, slow transient outward; I_Kur, ultra-rapid K⁺ delayed rectifier; I_Ks, slow K⁺ delayed rectifier; I_Kr, rapid K⁺ delayed rectifier; I_K1, inward rectifier; I_KATP, ADP-activated K⁺ channel; I_KACh, muscarinic-gated K⁺ channel; I_f, “funny” current; I_NCX, Na⁺/Ca²⁺ exchange current.