Table 2.

EC₅₀ values for the binding of PCSK9 variants to LDLR, as determined by solid-phase immunoassay at pH 7.2 and pH 5.5.

	EC50 (nM)*
	pH 7.2	pH 5.5
Wild-type	112.2 ± 16.8	23.2 ± 3.7
p.(Asp374Tyr)	19.3 ± 9.4	7.4 ± 1.7
p.(Pro331Ala)	97.6 ± 21.7	25.5 ± 7.7
p.(Arg357Cys)	50.9 ± 13.6	13.3 ± 6.7
p.(Ser636Arg)	47.4 ± 7.1	13.9 ± 5.5
p.(His643Arg)	93.7 ± 13.4	44.2 ± 3.2

^*Data are reported as mean ± standard deviation.