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. 2017 Nov 10;7:15303. doi: 10.1038/s41598-017-14105-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of 5 mg/kg Albu-CocH1 and diazepam on cocaine-induced locomotor activity and toxicity in rats. (A–C) Rats (n = 8 per group) were allowed to acclimate to the test chambers for 60 min before i.p. administration of saline or 60 mg/kg cocaine. (A) 5 mg/kg Albu-CocH1 (i.v.) or (B) 5 mg/kg diazepam (i.p.) was administered at t = 30 min or (C) t = 60 min (Albu-CocH1 only) after the cocaine administration. Vertical red dashed lines indicate the time points when the interventions were introduced. Data are plotted as the mean ± s.e.m. meters traveled in 5-min bin during 7-hour tests. (D) Occurrence of convulsions and death in protection and rescue experiments. p < 0.001 (or ***) indicates the significant difference in the cocaine-induced hyperactivity/convulsion/lethality between the treated group and the corresponding untreated group.