Table 1.

Effects of diazepam and CocH1-HSA on cocaine (180 mg/kg, i.p.) induced convulsion and lethality in rats.

Drugs used	Expt. method	Number of rats	Time after cocaine injection (min)
			Convulsion	Death	Recoveryf
Cocaine (180 mg/kg)	Controla	10	2.78 ± 1.03	4.07 ± 1.87	N.A.
Cocaine (180 mg/kg) and Diazepam (5 mg/kg)	Protectionb	10 (i.p.)	N.O.	9.10 ± 2.11	N.A.
		4 (i.v.)	9.10 (one rat)	9.91 ± 5.55	N.A
	Rescuec	10 (i.p.)	2.75 ± 1.95	4.13 ± 2.76	N.A.
		4 (i.v.)	2.84 ± 1.91	4.14 ± 2.17	N.A.
Cocaine (180 mg/kg) and CocH1-HAS (5 mg/kg)	Protectiond	10	N.O.	N.O.	N.A.
	Rescuee	10	2.82 ± 1.92	N.O.	4.2 ± 1.91

^aControl experiment was performed by administration of 180 mg/kg cocaine (i.p.).

^bProtection experiment was performed by pretreatment of rats with 5 mg/kg diazepam (i.p. for 10 rats and i.v. for 4 rats) 5 min (if i.p.) or 1 min (if i.v.) before administration of 180 mg/kg cocaine (i.p.).

^cRescue experiment was carried out by first administration of 180 mg/kg cocaine (i.p.). Then, in 1 min after the onset of cocaine-induced convulsion, rats were given 5 mg/kg diazepam (i.p. for 10 rats and i.v. for 4 rats).

^dProtection experiment was performed by pretreatment of rats with 5 mg/kg CocH1-HSA (i.v.) 1 min before administration of 180 mg/kg cocaine (i.p.).

^eRescue experiment was carried out by first administration of 180 mg/kg cocaine (i.p.). Then, in 1 min after the onset of cocaine-induced convulsion, rats were given 5 mg/kg CocH1-HSA (i.v.).

^fThe clock time (starting from the cocaine administration) when the rats were fully recovered (occurrence of righting reflex and normal walk) from cocaine-induced convulsion.