Table 1.
Drugs used | Expt. method | Number of rats | Time after cocaine injection (min) | ||
---|---|---|---|---|---|
Convulsion | Death | Recoveryf | |||
Cocaine (180 mg/kg) | Controla | 10 | 2.78 ± 1.03 | 4.07 ± 1.87 | N.A. |
Cocaine (180 mg/kg) and Diazepam (5 mg/kg) | Protectionb | 10 (i.p.) | N.O. | 9.10 ± 2.11 | N.A. |
4 (i.v.) | 9.10 (one rat) | 9.91 ± 5.55 | N.A | ||
Rescuec | 10 (i.p.) | 2.75 ± 1.95 | 4.13 ± 2.76 | N.A. | |
4 (i.v.) | 2.84 ± 1.91 | 4.14 ± 2.17 | N.A. | ||
Cocaine (180 mg/kg) and CocH1-HAS (5 mg/kg) | Protectiond | 10 | N.O. | N.O. | N.A. |
Rescuee | 10 | 2.82 ± 1.92 | N.O. | 4.2 ± 1.91 |
aControl experiment was performed by administration of 180 mg/kg cocaine (i.p.).
bProtection experiment was performed by pretreatment of rats with 5 mg/kg diazepam (i.p. for 10 rats and i.v. for 4 rats) 5 min (if i.p.) or 1 min (if i.v.) before administration of 180 mg/kg cocaine (i.p.).
cRescue experiment was carried out by first administration of 180 mg/kg cocaine (i.p.). Then, in 1 min after the onset of cocaine-induced convulsion, rats were given 5 mg/kg diazepam (i.p. for 10 rats and i.v. for 4 rats).
dProtection experiment was performed by pretreatment of rats with 5 mg/kg CocH1-HSA (i.v.) 1 min before administration of 180 mg/kg cocaine (i.p.).
eRescue experiment was carried out by first administration of 180 mg/kg cocaine (i.p.). Then, in 1 min after the onset of cocaine-induced convulsion, rats were given 5 mg/kg CocH1-HSA (i.v.).
fThe clock time (starting from the cocaine administration) when the rats were fully recovered (occurrence of righting reflex and normal walk) from cocaine-induced convulsion.