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. 2017 Nov 10;7:15285. doi: 10.1038/s41598-017-15325-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Generation of microtissues from human xenograft HCT116 tumors and MIA PaCa-2 tumors. (A) Microtissue production image using a vibratome with a sapphire knife to generate tumor slices for microtissue generation using a 1 mm unicore punch. (B) HCT116 tissue slice (0.5 uM thick) with microtissues harvested using 1 mm Harris Uni-core punch. (C) HCT 116 Spheroid (D) Definiens software border detection analysis of HCT 116 spheroid. (E) Average mass of microtissues (n = 3) from 3 tumor slices, no significant difference. (F) Definiens total pixel count analysis of microtissue, n = 3 CV 7.5% SD ns. (G) Average OCR of MIA PaCa-2 tumor derived microtissues (n = 26). (H) Corresponding ECAR of each microtissue from Fig. 3G. (I) Scatter plot of OCR vs ECAR of each microtissue, a linear trend is observed but not significant.