Figure 2.

GMSCs ameliorated the development and severity of T1DM in mice. T1DM was induced in male C57BL/6-FoxP3^gfp mice using multiple low doses of STZ injection, 1 × 10⁶ GMSCs or human skin fibroblast cells were injected into mice via intraperitoneal route on days 0, 7, 14, 21, 28. (a) Incidence of diabetes. Blood glucose concentration exceeding 300 mg/dL in two consecutive daily measurements was considered diabetes. (b) Non-fasting blood glucose of mice in three groups. (c) Body weight in different groups. Data are presented as the mean ± SEM from two independent experiments (n = 5). ***P < 0.001, versus the fibroblast or model groups.