Table 3.
Univariate analysis of different prognostic variables in DSS and RFS of NCL-HCC patients using the Cox proportional hazard model. Abbreviations: 95% CI = 95% confidence interval; HR = hazard ratio; TNM stage = tumour node metastasis; P-value < 0.05.
| Variables | DSS | RFS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Sex | ||||||
| male/female | 0.494 | 0.101–2.431 | 0.386 | 0.528 | 0.109–2.548 | 0.426 |
| Age(years) | ||||||
| ≤50/>50 | 0.983 | 0.306–3.163 | 0.977 | 1.145 | 0.356–3.678 | 0.821 |
| AFP(ng/ml) | ||||||
| ≤20/>20 | 0.579 | 0.192–1.744 | 0.331 | 0.815 | 0.272–2.443 | 0.715 |
| HBsAg | ||||||
| yes/no | 0.328 | 0.030–3.560 | 0.359 | 0.409 | 0.038–4.390 | 0.460 |
| Tumor size(cm) | ||||||
| ≤5/>5 | 3.768 | 1.089–13.035 | 0.036 | 2.873 | 0.841–9.818 | 0.092 |
| Multiplicity | ||||||
| Single/multiple | 0.462 | 0.061–3.501 | 0.455 | 0.440 | 0.059–3.275 | 0.423 |
| Intrahepatic Metastasis | ||||||
| yes/no | 13.071 | 1.343–27.203 | 0.027 | 10.985 | 1.206–31.072 | 0.033 |
| TNM stage | ||||||
| (I/II)/(III/VI) | 1.255 | 2.080–3.807 | 0.020 | 1.295 | 0.093–2.937 | 0.039 |
| Vascular Invasion | ||||||
| yes/no | 1.078 | 1.010–2.635 | 0.017 | 1.116 | 0.015–1.866 | 0.036 |
| Tumor Differentiation | ||||||
| Poor/well | 0.854 | 0.210–0.856 | 0.362 | 0.752 | 0.136–0.873 | 0.219 |
| PKM2 expression | ||||||
| low/high | 5.126 | 1.383–9.003 | 0.014 | 4.100 | 4.178–14.268 | 0.027 |