Table 5.

Multivariate analysis of different prognostic variables in DSS and RFS of NCL-HCC patients using the Cox proportional hazard model.

Variables	DSS			RFS
	HR	95%CI	P value	HR	95%CI	P value
Model 1
AFP(ng/ml)
≤20/>20	0.817	0.311–2.148	0.682	0.851	0.323–2.236	0.743
HBsAg
yes/no	0.956	0.127–7.221	0.966	0.961	0.127–7.529	0.970
Model 2
AFP(ng/ml)
≤20/>20	0.875	0.331–2.313	0.788	0.935	0.354–2.471	0.892
HBsAg
yes/no	0.634	0.080–4.994	0.665	0.638	0.081–5.025	0.669
PKM2 expression
low/high	3.960	1.464–10.712	0.007	3.812	1.417–10.254	0.008
Model 3
AFP(ng/ml)
≤20/>20	0.627	0.217–1.815	0.390	0.862	0.298–2.494	0.784
HBsAg
yes/no	0.247	0.025–2.422	0.230	0.306	0.032–2.932	0.304
Tumor size (cm)
≤5/>5	3.734	1.160–12.020	0.027	2.904	0.899–4.381	0.045
Intrahepatic Metastasis
yes/no	5.832	1.980–17.095	0.011	5.354	1.810–10.261	0.012
TNM stage
(I/II)/(III/VI)	1.260	0.487–1.776	0.016	2.276	1.093–3.818	0.020
Vascular Invasion
yes/no	1.108	0.217–1.676	0.017	1.312	1.021–3.819	0.030
Tumor Differentiation
Poor/well	2.387	1.302–2.406	0.033	1.891	1.520–3.845	0.028
PKM2 expression
low/high	4.857	1.534–15.375	0.007	3.996	1.314–12.154	0.015

Abbreviations: 95% CI = 95% confidence interval; HR = hazard ratio; TNM stage = tumour node metastasis; P-value < 0.05.