Table 1.
Baseline patient characteristics by BMI
| SC abatacept | IV abatacept | Pooled SC/IV abatacept | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Underweight/ normal BMI n = 265 |
Overweight BMI n = 249 |
Obese BMI n = 221 |
Underweight/ normal BMI n = 261 |
Overweight BMI n = 248 |
Obese BMI n = 212 |
Underweight/ normal BMI n = 526 |
Overweight BMI n = 497 |
Obese BMI n = 433 |
|
| BMI, kg/m2 | 22.0 (2.2) | 27.2 (1.4) | 35.2 (5.1) | 22.0 (2.1) | 27.5 (1.5) | 35.3 (5.4) | 22.0 (2.1) | 27.4 (1.4) | 35.2 (5.2) |
| Age, years | 46.0 (14.3) | 51.4 (12.4) | 53.0 (11.4) | 49.0 (14.3) | 51.2 (12.1) | 50.1 (10.7) | 47.5 (14.4) | 51.3 (12.2) | 51.6 (11.2) |
| Females, % | 84.9 | 78.7 | 90.0 | 81.2 | 79.0 | 81.1 | 83.1 | 78.9 | 85.7 |
| Caucasians, % | 72.1 | 77.1 | 75.1 | 69.7 | 75.4 | 79.2 | 70.9 | 76.3 | 77.1 |
| RA duration, years | 8.2 (8.0) | 7.1 (6.8) | 7.6 (9.4) | 8.3 (8.3) | 8.2 (8.2) | 6.2 (6.6) | 8.3 (8.2) | 7.7 (7.5) | 6.9 (8.2) |
| TJC28 | 16.4 (6.6) | 17.0 (6.4) | 17.5 (6.2) | 16.3 (6.6) | 16.9 (6.4) | 17.3 (6.3) | 16.3 (6.6) | 16.9 (6.4) | 17.4 (6.2) |
| SJC28 | 14.2 (5.8) | 14.0 (5.4) | 14.6 (5.5) | 13.8 (5.4) | 14.2 (5.5) | 13.6 (5.1) | 14.0 (5.6) | 14.1 (5.4) | 14.1 (5.3) |
| hsCRP, mg/dL | 3.2 (3.6) | 2.5 (2.5) | 2.1 (2.3) | 3.0 (3.3) | 2.5 (2.7) | 2.6 (2.8) | 3.1 (3.4) | 2.5 (2.6) | 2.3 (2.5) |
| HAQ-DI | 1.7 (0.7) | 1.7 (0.7) | 1.8 (0.7) | 1.6 (0.7) | 1.7 (0.7) | 1.7 (0.7) | 1.7 (0.7) | 1.7 (0.7) | 1.8 (0.7) |
| DAS28 (CRP) | 6.3 (0.9) | 6.2 (0.9) | 6.3 (0.8) | 6.2 (0.8) | 6.2 (0.9) | 6.3 (0.8) | 6.2 (0.9) | 6.2 (0.9) | 6.3 (0.8) |
| PtGA, 100 mm VAS | 67.8 (19.1) | 65.8 (20.6) | 66.7 (21.6) | 64.8 (19.9) | 64.0 (19.9) | 66.3 (20.2) | 66.3 (19.5) | 64.9 (20.3) | 66.5 (20.9) |
Data are mean (standard deviation) unless indicated otherwise
BMI body mass index, CRP C-reactive protein, DAS28 Disease Activity Score 28, HAQ-DI Health Assessment Questionnaire-Disability Index, hsCRP high-sensitivity CRP, IV intravenous, PtGA patient global assessment, RA rheumatoid arthritis, SC subcutaneous, SJC28 swollen joint count-28 joints, TJC28 tender joint count-28 joints, VAS visual analogue scale