Table 2.
Clinical response or mean change from baseline at month 6 by BMI
| SC abatacept | IV abatacept | Pooled SC/IV abatacept | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Underweight/ normal BMI |
Overweight BMI | Obese BMI | Underweight/ normal BMI |
Overweight BMI | Obese BMI | Underweight/ normal BMI |
Overweight BMI | Obese BMI | |
| TJC28 | −11.8 (0.4) (−12.6, −11.0) |
−11.2 (0.5) (−12.1, −10.3) |
−11.9 (0.5) (−12.9, −10.9) |
−10.9 (0.4) (−11.7, −10.1) |
−11.6 (0.4) (−12.5, −10.8) |
−11.5 (0.5) (−12.4, −10.6) |
−11.4 (0.3) (−11.9, −10.8) |
−11.4 (0.3) (−12.0, −10.8) |
−11.7 (0.4) (−12.4, −11.0) |
| SJC28 | −10.3 (0.4) (−11.1, −9.6) |
−8.2 (0.4) (−8.9, −7.4) |
−10.3 (0.4) (−11.2, −9.5) |
−9.7 (0.3) (−10.3, −9.0) |
−8.8 (0.4) (−9.6, −8.1) |
−9.8 (0.4) (−10.5, −9.0) |
−10.0 (0.3) (−10.5, −9.5) |
−8.5 (0.3) (−9.0, −8.0) |
−10.0 (0.3) (−10.6, −9.5) |
| hsCRP, mg/dL | −2.0 (0.2) (−2.4, −1.7) |
−1.5 (0.2) (−1.8, −1.2) |
−0.7 (0.2) (−1.0, −0.4) |
−1.9 (0.2) (−2.3, −1.5) |
−1.4 (0.2) (−1.8, −1.1) |
−1.1 (0.2) (−1.5, −0.7) |
−2.0 (0.1) (−2.2, −1.7) |
−1.5 (0.1) (−1.7, −1.2) |
−0.9 (0.1) (−1.1, −0.6) |
| DAS28 (CRP) remission, % (95% CI) | 27.3 (21.7, 32.9) |
20.0 (14.9, 25.1) |
25.4 (19.4, 31.4) |
25.0 (19.5, 30.5) |
30.0 (24.0, 35.9) |
18.5 (13.0, 23.9) |
26.2 (22.2, 30.1) |
24.9 (20.9, 28.8) |
22.0 (17.9, 26.0) |
| SDAI remission, % (95% CI) | 9.1 (5.5, 12.7) |
12.0 (7.8, 16.1) |
11.9 (7.5, 16.4) |
10.6 (6.7, 14.6) |
11.5 (7.3, 15.7) |
9.8 (5.6, 14.0) |
9.9 (7.2, 12.5) |
11.7 (8.8, 14.7) |
10.9 (7.8, 14.0) |
| CDAI remission, % (95% CI) | 9.0 (5.4, 12.6) |
13.1 (8.8, 17.4) |
14.3 (9.5, 19.1) |
11.8 (7.7, 15.9) |
13.7 (9.2, 18.1) |
11.8 (7.3, 16.3) |
10.4 (7.6, 13.1) |
13.4 (10.3, 16.5) |
13.1 (9.8, 16.4) |
| PtGA, 100 mm VAS | −36.7 (1.6) (−39.8, −33.6) |
−35.8 (1.7) (−39.1, −32.4) |
−33.8 (2.0) (−37.7, −29.8) |
−34.7 (1.7) (−37.9, −31.4) |
−33.8 (1.7) (−37.1, −30.6) |
−30.8 (2.0) (−34.8, −26.9) |
−35.7 (1.2) (−37.9, −33.4) |
−34.8 (1.2) (−37.1, −32.5) |
−32.3 (1.4) (−35.1, −29.5) |
Data are mean (standard deviation) (95% confidence interval) change from baseline unless indicated otherwise
CDAI Clinical Disease Activity Index, CRP C-reactive protein, DAS28 Disease Activity Score 28, hsCRP high-sensitivity CRP, IV intravenous, PtGA patient global assessment, SC subcutaneous, SDAI Simplified Disease Activity Index, SJC28 swollen joint count-28 joints, TJC28 tender joint count-28 joints, VAS visual analogue scale