Table 5.

Factors associated with renal dysfunction in RA patients

	OR	95% CI	p value
Absolute eGFR-based renal dysfunction
Age (≥ 65 years)	7.24	5.71–9.18	< 0.001
Female sex	3.12	2.29–4.24	< 0.001
BMI (> 25)	0.59	0.44–0.78	< 0.001
Hypertension	2.22	1.76–2.80	< 0.001
Serum LDL-C (≥ 140 mg/dl)	1.38	1.01–1.89	0.046
NSAID use	0.77	0.60–1.00	0.050
Cumulative steroid dose (≥ 5.5 g)	1.40	1.00–1.95	0.049
BSA-indexed eGFR-based renal dysfunction
Age (≥ 65 years)	5.19	3.83–7.05	< 0.001
Female sex	1.38	0.99–1.92	0.061
RA duration (≤ 3 years)	0.72	0.51–1.01	0.058
Serum CRP levels	1.12	0.99–1.27	0.068
Hypertension	3.05	2.37–3.96	< 0.001
NIDDM	1.52	1.06–2.18	0.022
Serum LDL-C (≥ 140 mg/dl)	1.53	1.08–2.17	0.016
Cumulative steroid dose (≥ 5.5 g)	1.45	1.01–2.08	0.047

Two separate multivariate logistic regression analyses were conducted to evaluate factors associated with the risk of renal dysfunction based on absolute eGFR and BSA-indexed eGFR. Independent factors that remained in the final models are shown. The final step yielded an AUC-ROC of 0.79 (95% CI 0.77–0.81, p < 0.001) for absolute eGFR-based renal dysfunction and 0.78 (95% CI 0.76–0.81, p < 0.001) for BSA-indexed eGFR-based renal dysfunction

RA rheumatoid arthritis, eGFR estimated glomerular filtration rate, BMI body mass index, LDL-C low-density lipoprotein cholesterol, NSAID nonsteroidal anti-inflammatory drug, BSA body surface area, CRP C-reactive protein, NIDDM non-insulin-dependent diabetes mellitus, OR odds ratio, 95% CI 95% confidence interval, AUC area under the curve, ROC receiver operating characteristics