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. 2017 Nov 10;7:15293. doi: 10.1038/s41598-017-15377-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced oxygen consumption levels and Increased levels of glycolysis in primary lymphocytes isolated from C57BL/6J-mt ^FVB/NJ compared with cells from C57BL/6J. (A) The oxygen consumption ratio (OCR) was measured in the primary lymphocytes from peripheral lymph nodes. Basal respiration and ATP production levels were significantly less in C57BL/6J-mt ^FVB/NJ compared to C57BL/6J. (B) The extracellular acidification rate (ECAR), which indicates glycolysis levels, in the primary lymphocytes was measured using a Seahorse XF analyzer. Data presented in the graph was normalized with the value of C57BL/6J. B6: C57BL/6J, FVB: C57BL/6J-mt ^FVB/NJ. ***P < 0.001, t test.