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. 2017 Nov 10;7:15277. doi: 10.1038/s41598-017-15475-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of miR-126 in serum, exosomes, and exosome-free serum in relation to tumour stage. Relative levels of miR-126 in serum (A), exosomes (B) and exosomes-free serum (C) in healthy control group (CTRL) and NSCLC patients of individual. (D) The ratio of circulating miR-126 in exosomes-free serum and serum of CTRL subjects and NSCLC patients at different tumour stages is shown. Statistical analyses were performed using one-way analysis of variance (ANOVA), with Tukey post-hoc analysis. The symbol “*” indicates significant differences compared to control with p < 0.05.