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. 2017 Nov 10;7:15277. doi: 10.1038/s41598-017-15475-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Biomarker performance in patients with NSCLC. Receiver-operating analysis of miR-126 detected in serum, exosomes and exosome-free serum. The areas under the receiver operating curves (AUC) were generated using miR-126 expression in serum, exosomes and exosome-free serum, discriminating healthy subjects (CTRL) from NSCLC patients at early (NSCLC-S-I/II) and advanced stages (NSCLC-S-III/IV). Differences with p < 0.05 were considered statistically significant.