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. 2017 Nov 10;7:15284. doi: 10.1038/s41598-017-15127-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ages at onset (1A), AFP serum levels (1B) and variability of latencies in respect of disease progression (SDFS) (1C) in AOA1, AOA2 and AT patients. Individual symbols (dots, triangles, squares) represent each patient’s age at onset (1 A), bar graphs represent the mean; upper and lower error bars represent standard error of the mean (1 A and 1B). *p < 0.05; **p < 0.01 and ****p < 0.0001 significant differences. Abbreviations: AFP: Alpha-fetoprotein; AOA1: ataxia with oculomotor apraxia type 1; AOA2: ataxia with oculomotor apraxia type 2; AT: Ataxia Telangiectasia;; SDFS: Spinocerebellar degeneration functional score.