Table 1.
Recipient | Donor | ||||||||
---|---|---|---|---|---|---|---|---|---|
ID | MHC haplotypes | Sex | ID | MHC haplotypes | Sex | Total cells transplanted | CD34 dose/kg | CD3 dose/kg | Outcome |
32851 | M1/M1 | M | 32847 | M1/M1 | M | 2.20 × 109 | 1.55 × 106 | N.D. | Primary engraftment failure |
32846 | M2/M3 | M | 32843 | M2/M3 | M | 8.50 × 109 | 5.26 × 106 | 3.74 × 108 | Secondary engraftment failure |
32849 | M3/M3 | M | 32843 | M3/M3 | M | 4.90 × 109 | 9.42 × 106 | 2.80 × 108 | Secondary engraftment failure |
32846* | M2/M3 | M | 32843 | M2/M3 | M | 1.49 × 109 | 4.43 × 106 | 6.40 × 107 | Primary engraftment failure |
33450 | M1/M3 | F | 33452 | M1/M3 | M | 1.05 × 1010 | 3.33 × 107 | 4.05 × 108 | Lethal GvHD |
33455 | M1/M3 | M | 33452 | M1/M3 | M | 6.27 × 109 | 1.06 × 107 | 3.73 × 108 | Lethal GvHD |
33454 | M2/M4 | F | 33461 | M2/M4 | M | 4.80 × 108 | 7.80 × 106 | 5.18 × 107 | Stable Chimerism |
34666 | M2/M6 | F | 33456 | M2/M6 | F | 1.60 × 109 | 8.84 × 106 | 1.06 × 108 | Stable Chimerism |
N.D. not determined
Table summarizes the eight HSCTs performed in this study, listed in chronological order. Asterisk (*) indicates the second transplant of recipient macaque 32846