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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Exp Neurol. 2016 May 28;283(Pt A):57–72. doi: 10.1016/j.expneurol.2016.05.037

Fig 6. Simulated effect of Stiripentol and benzodiazepine on ictal-like activity.

Fig 6

(A) Example of simulated course of seizure with background activity with interictal spikes at the beginning following by fast-onset activity, seizure and seizure termination. (B) Action of Stiripentol (STP) on the course of seizure (A) is presented. STP enhances the activity of the GABAA receptors. Examination of mIPSCs (miniature GABAA receptor–mediated currents) kinetics indicated that STP also markedly increased the mIPSC decay-time constant [12]. Enhanced activity of the GABAA receptors increased shunting effect. We represented shunting effect in the model by reducing the membrane potential with increasing of IPSPS decay-time constant. Prolonged IPSC decay time is concentration dependent. (C) Action of benzodiazepine (BZD), increasing the amplitude of IPSC, on the course of seizure (A) is presented. (D) Combined action of BZD and STP conducts to background activity.