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. 2017 Nov 10;8:259. doi: 10.1186/s13287-017-0699-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Biodistribution and homing of bone marrow mononuclear cells (BMMCs). a Representative coronal whole-body SPECT/CT images of control (C) and silicotic (SIL) animals 2 h after intravenous administration of ^99mTc-BMMCs derived from heathy or silicotic (sil) donors. ^99mTc-BMMCs migrate to the liver in all experimental groups (Li). B bladder. n = 4 animals per group. b Representative photomicrographs of lung parenchyma, granuloma, and spleen after immunohistochemistry with green fluorescent protein (GFP) antibody. Rare inflammatory GFP⁺ cells (black arrows) were observed in lung parenchyma and in granulomas of the SIL-BMMC groups 24 h after treatment with BMMCs from GFP⁺ mice. Spleens of GFP male mice were used as positive control. Bars, 100 μm. n = 4 animals per group