Table 1.
Lung inflammation: total number of cells, number of mononuclear and polymorphonuclear cells in lung tissue
| MN (%) | PMN (%) | Total (%) | |
|---|---|---|---|
| Lung parenchyma | |||
| C-Sal | 35.8 ± 3.3 | 5.8 ± 1.6 | 41.6 ± 3.1 |
| C-BMMC-healthy | 37.0 ± 4.3 | 5.2 ± 2.3 | 42.2 ± 5.1 |
| C-BMMC-sil | 33.1 ± 3.1 | 6.0 ± 1.9 | 39.1 ± 3.8 |
| SIL-Sal | 42.6 ± 3.3* | 8.2 ± 2.3 | 50.9 ± 2.9* |
| SIL- BMMC-healthy | 38.3 ± 4.4# | 5.1 ± 2.8# | 43.3 ± 4.2# |
| SIL- BMMC-sil | 35.3 ± 2.1# | 5.8 ± 3.3 | 41.2 ± 4.2# |
| Granuloma | |||
| SIL-Sal | 38.8 ± 1.5 | 11.3 ± 2.3 | 50.1 ± 2.0 |
| SIL- BMMC-healthy | 36.2 ± 2.8 | 7.2 ± 3.2# | 43.5 ± 4.3# |
| SIL- BMMC-sil | 34.2 ± 2.5# | 6.8 ± 2.7# | 41.0 ± 3.7# |
Control (C) and silicotic (SIL) mice received saline (50 μL) or silica (20 mg silica/50 μL saline) (Sal) intratracheally. C and SIL animals were treated with bone marrow mononuclear cells (BMMCs) (2 × 106 cells) derived from healthy or silicotic (sil) donors. MN mononuclear cells, PMN polymorphonuclear cells, total total cellularity. Values are means ± SD. N = 10 animals per group. *Significantly different from C-Sal (P < 0.05). #Significantly different from SIL-Sal (P < 0.05)