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. 2017 Nov 10;16:170. doi: 10.1186/s12943-017-0736-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — HDAC7 regulates STAT3 phosphorylation. a. Representative Western blot (left panel) and statistics analyses of the phosphorylation of Stat3 proteins in individual lung tumors isolated from Hdac7 ^+/−/K-Ras and control mice. b, Representative Western blot (left panel) and quantitative (right panel) analyses of Stat3 phosphorylation level in H1299 cells expressing shHDAC7 and scramble shRNA. c, HDAC7 overexpression significantly abrogates STAT3 phosphorylation. Representative Western blot analyses of STAT3 phosphorylation level in H1299 cells transfected with pMX-Hdac7 and pMX control plasmids. The values in statistics analyses in (a and b) represent the means ± SD. of three separate experiments. ***, p<0.001