Fig. 6.

CSF YKL-40 in the differential diagnosis of neurodegenerative dementia. a CSF YKL-40 in NC (n = 62), sCJD (n = 84), AD (n = 84), DLB/PDD (n = 40) and VaD (n = 20) cases (cohort 1). Number of cases analyzed and statistical significance of differences between groups is indicated. Kruskal-Wallis and Dunn’s post-hoc tests were used for estimation of statistical differences. b ROC curves for YKL-40 quantification in the differential diagnosis of dementia groups compared to NC. In the legend, AUC values, corresponding to the area under ROC curves, and 95% confidence intervals are reported. Diagnostic parameters (cut-off, sensitivity and specificity) are indicated for NC versus sCJD comparison. c Stratification of AD cases in slow progressive (AD) (n = 64) and rapid progressive (rpAD) (n = 20) cases. Statistical differences were tested with Mann–Whitney test. d Stratification of sCJD cases according to PRNP codon 129 polymorphism (MM, n = 40, MV, n = 22 and VV, n = 20). Kruskal-Wallis and Dunn’s post-hoc tests were used for statistical differences estimation. ***p < 0.001