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Independent validation of increased CSF YKL-40 level in sCJD patients. a CSF YKL-40 levels in HC (n = 35), AD (n = 28) and sCJD (n = 35) cases (cohort 2). Kruskal-Wallis and Dunn’s post-hoc tests were used for statistical differences estimation. b CSF YKL-40 levels in Cognitive Impairment/Dementia (n = 26) and sCJD cases (n = 14) (cohort 3). Statistical differences were estimated with the Mann–Whitney test.**p < 0.01, ***p < 0.001
