Table 3.
Common Variants | |||||||
Gene | SNP ID | MAF | p-value | FDR | Model | ||
Dyslipidemia | EIF4B | rs146008363 | 0.05 | 0.00018 | 0.180 | DOM | |
OGFOD3 | rs62079523 | 0.33 | 0.00032 | 0.180 | DOM | ||
Extreme phenotype | BAD | rs2286615 | 0.10 | 0.00034 | 0.200 | DOM | |
FCRL3 | rs2282284 | 0.03 | 0.00042 | 0.200 | DOM | ||
Common/Rare variants | |||||||
Gene | Rare (n) | Common (n) | p-value | FDR | |||
Extreme phenotype | BAD | 3 | 1 | 5.79x10-5 | 0.087 | ||
FCRL3 | 2 | 1 | 3.86x10-5 | 0.087 | |||
EIF4B | 1 | 1 | 0.00010 | 0.100 |
MAF Minor allele frequency, DOM Dominant effect, Rare (n) Number of rare variants analyzed in the gene, Common (n) Number of common variants analyzed in the gene, Extreme phenotype Three and more cardiometabolic risk factor