Table 4.

Significant genetic associations with methotrexate and corticosteroid candidate genes

Common Variants
	Gene	SNP ID	MAF	p-value	FDR	Model
Dyslipidemia	BAD	rs2286615	0.10	0.00065	0.021	ADD
	APOB	rs676210	0.23	0.0069	0.110	DOM
Extreme phenotype	BAD	rs2286615	0.10	0.00034	0.0089	ADD, DOM
Insulin resistance	BAD	rs2286615	0.10	0.0044	0.069	DOM
	SERPINA6	rs2228541	0.50	0.0051	0.069	ADD, DOM, REC
Obesity	BAD	rs2286615	0.10	0.0025	0.081	ADD, DOM
Rare variants
	Gene	Rare (n)		p-value	FDR
Extreme phenotype	NR3C1	2		0.0021	0.17
Pre-hypertension	CRHR1	1		0.0025	0.20
	CRHR2	2		0.0048	0.20
Common/Rare variants
	Gene	Rare (n)	Common (n)	p-value	FDR
Dyslipidemia	BAD	3	1	0.00049	0.040
	APOB	30	3	0.0028	0.12
	CBS	3	0	0.0042	0.12
	SLCO4C1	4	0	0.0066	0.14
Extreme phenotype	BAD	3	1	3.35x10-5	0.0028
	NR3C1	2	0	0.0037	0.15
Pre-hypertension	CRHR1	1	0	0.0032	0.14
	CRHR2	2	0	0.0033	0.14

MAF Minor allele frequency, DOM Dominant effect, ADD Additive effect, REC Recessive effect, Rare (n) Number of rare variants analyzed in the gene, Common (n) Number of common variants analyzed in the gene, Extreme phenotype Three and more cardiometabolic risk factor