Table 5.

Logistic regression model with significant cardiometabolic candidate genes

	Extreme Phenotype				Dyslipidemia
	BAD/rs2286615 (C, DOM)	FCRL3/rs2282284 (C,DOM)	BAD (CR)	FCRL3 (CR)	OGFOD3/rs62079523 (C, DOM)
	OR (95% CI) p-value
Age	1.219 (1.005-1.478)	1.151 (0.993-1.334)	1.213 (1.017-1.447)	1.150 (0.993-1.332)	1.033 (0.962-1.109)
	0.044	0.062	0.032	0.062	0.374
Gender	1.152 (0.216-6.142)	1.062 (0.268-4.201)	1.624 (0.340-7.749)	1.039 (0.266-4.063)	0.720 (0.360-1.439)
	0.869	0.932	0.543	0.956	0.352
Corticoid	1.000 (1.000-1.000)	1.000 (1.000-1.000)	1.000 (1.000-1.000)	1.000 (1.000-1.000)	1.000 (1.000-1.000)
	0.577	0.570	0.355	0.574	0.528
Asparaginase	1.000 (1.000-1.000)	1.000 (1.000-1.000)	1.000 (1.000-1.000)	1.000 (1.000-1.000)	1.000 (1.000-1.000)
	0.714	0.158	0.444	0.270	0.346
Methotrexate	0.999 (0.999-1.000)	1.000 (0.999-1.000)	0.999 (0.999-1.000)	1.000 (0.999-1.000)	1.000 (1.000-1.000)
	0.075	0.800	0.048	0.729	0.696
CRT	14.506 (1.116-188.530)	4.938 (0.687-35.491)	16.098 (1.220-212.463)	3.544 (0.561-22.385)	1.708 (0.668-4.366)
	0.041	0.112	0.035	0.178	0.264
Energy balance	0.999 (0.998-1.001)	0.999 (0.998-1.000)	1.000 (0.998-1.001)	0.999 (0.999-1.000)	1.000 (0.999-1.000)
	0.297	0.304	0.421	0.306	0.210
Med score	0.652 (0.319-1.329)	0.884 (0.518-1.509)	0.752 (0.374-1.513)	0.815 (0.491-1.353)	1.008 (0.807-1.259)
	0.239	0.651	0.425	0.430	0.944
SNP	57.900 (3.152-1063.462)	67.983 (3.393-1362.288)	68.819 (4.202-1159.995)	11.695 (1.150-118.907)	2.712 (1.352-5.442)
	0.006	0.006	0.003	0.038	0.005

Top: Odds ratio [95% CI], bottom: p-value

Boldface: significant association

C common, CR common/rare, DOM Dominant effect, CRT Cranial radiotherapy, Med score Mediterranean diet score, Extreme phenotype Three and more cardiometabolic risk factor